Structure of the hexameric fungal plasma membrane proton pump in its autoinhibited state
Sabine Heit, Maxwell M. G. Geurts, Bonnie J. Murphy, Robin A. Corey, Deryck J. Mills, Werner Kühlbrandt, Maike Bublitz
Abstract
by electron cryo-microscopy at 3.3-Å resolution, elucidating the molecular basis for hexamer formation and autoinhibition and providing a basis for structure-based drug development. Coarse-grained molecular dynamics simulations in a lipid bilayer suggest lipid-mediated contacts between monomers and a substantial protein-induced membrane deformation that could act as a proton-attracting funnel.
Topics & Concepts
PlasmaMembraneState (computer science)ProtonChemistryBiophysicsCell biologyBiologyBiochemistryPhysicsComputer scienceAlgorithmQuantum mechanicsPhotosynthetic Processes and MechanismsATP Synthase and ATPases ResearchRNA and protein synthesis mechanisms