<i>N</i> <sup>6</sup> -methyladenosine of chromosome-associated regulatory RNA regulates chromatin state and transcription
Jun Liu, Xiaoyang Dou, Chuanyuan Chen, Chuanyuan Chen, Chuan Chen, Chuan Chen, Chang Liu, Meng Xu, Siqi Zhao, Bin Shen, Yawei Gao, Dali Han, Chuan He
Abstract
A new layer of transcriptional control N 6 -methyladenosine (m 6 A) is the most abundant messenger RNA modification in almost all eukaryotes. Liu et al. now show that m 6 A is also cotranscriptionally added onto various chromosome-associated regulatory RNAs (carRNAs) in mammalian cells. Disruption of m 6 A modification of these RNAs increases their abundance and promotes gene transcription by increasing the chromatin accessibility. Thus, m 6 A serves as a switch to regulate carRNA levels by tuning nearby chromatin state and downstream transcription. Science , this issue p. 580
Topics & Concepts
ChromatinTranscription (linguistics)RNABiologyCell biologyGeneGeneticsMolecular biologyChemistryLinguisticsPhilosophyRNA modifications and cancerCancer-related gene regulationRNA and protein synthesis mechanisms