Piezo1 channels restrain regulatory T cells but are dispensable for effector CD4 <sup>+</sup> T cell responses
Amit Jairaman, Shivashankar Othy, Joseph L. Dynes, Andriy V. Yeromin, Angel Zavala, Milton L. Greenberg, Jamison L. Nourse, Jesse R. Holt, Stuart M. Cahalan, Francesco Marangoni, Ian Parker, Medha M. Pathak, Michael D. Cahalan
Abstract
Mechanosensitive Piezo1 channels restrict regulatory T cell expansion and limit disease remission in EAE.
Topics & Concepts
Mechanosensitive channelsPIEZO1EffectorCell biologyCellBiologyT cellImmunologyGeneticsIon channelImmune systemReceptorErythrocyte Function and PathophysiologyBlood properties and coagulationLiterature, Magical Realism, García Márquez