Leptospirosis in India: a systematic review and meta-analysis of clinical profile, treatment and outcomes.
Nitin Gupta, William Wilson, Prithvishree Ravindra
Abstract
Introduction: Leptospirosis is a zoonotic bacterial infection with significant mortality and morbidity, especially in resource-limited settings. This systematic review aimed to study the clinical profile and outcome of patients with leptospirosis in India. Methodology: All articles up to 02.08.2022 were searched using the two databases, PubMed and Scopus. A total of 542 articles were found using the search terms related to 'leptospirosis' and 'India'. After two rounds of screening, 55 articles were included. The data were collected on epidemiology, clinical features, laboratory features and treatment of patients with leptospirosis. Results: =93%, P<0.001]. Conclusions: Leptospirosis is associated with significant mortality in Indian settings. There is a need for studies focussing on treatment modalities.