Estrogen-induced circRNA, circPGR, functions as a ceRNA to promote estrogen receptor-positive breast cancer cell growth by regulating cell cycle-related genes
Lei Wang, Yi Jia, Lingyun Lu, Yueying Zhang, Lan Wang, Guo-Sheng Hu, Yichen Liu, Jian‐cheng Ding, Haifeng Shen, Fangqing Zhao, Haihua Huang, Wen Liu
Abstract
These findings reveled that, besides the well-known messenger RNA (mRNA), microRNA (miRNA), long non-coding RNA (lncRNA) and enhancer RNA (eRNA) programs, estrogen also induced a circRNA program, and exemplified by circPGR, these estrogen-induced circRNAs were required for ER-positive breast cancer cell growth, providing a new class of therapeutic targets for ER-positive breast cancer.
Topics & Concepts
Competing endogenous RNACarcinogenesisBiologyEstrogen receptormicroRNACancer researchCell growthBreast cancerCircular RNAEstrogen receptor alphaCell cycleEstrogenFulvestrantLong non-coding RNACellRNAComputational biologyCancerGeneGeneticsCircular RNAs in diseasesMicroRNA in disease regulationCancer-related molecular mechanisms research