Ligand- and Substrate-Controlled <i>para</i> C–H Borylation of Anilines at Room Temperature
Chabush Haldar, Ranjana Bisht, Jagriti Chaturvedi, Saikat Guria, Mirja Md Mahamudul Hassan, Bali Ram, Buddhadeb Chattopadhyay
Abstract
A new catalytic method for para borylation of unprotected anilines is described. The catalytic method is developed by designing a new type of ligand framework that enables para borylation at room temperature. We showed that whereas previously reported para borylation of 2-substituted anilines required multistep protection/deprotection sequences and a high reaction temperature, our method gives a straightforward solution for achieving para borylation without such protection/deprotection chemistry at room temperature.
Topics & Concepts
BorylationChemistryLigand (biochemistry)Substrate (aquarium)CatalysisCombinatorial chemistryOrganic chemistryArylOceanographyGeologyAlkylReceptorBiochemistryCatalytic C–H Functionalization MethodsOrganoboron and organosilicon chemistryCatalytic Cross-Coupling Reactions