Sulfur Availability Impacts Accumulation of the 2-Thiouridine tRNA Modification in Bacillus subtilis
A. Edwards, Katherine A. Black, Patricia C. Dos Santos
Abstract
The 2-thiouridine (s 2 U) tRNA modification is found ubiquitously across all domains of life. YrvO and MnmA, the enzymes involved in this modification, are essential in B. subtilis , confirming the well-established role of s 2 U in maintaining translational efficiency and, consequently, cellular viability.
Topics & Concepts
Bacillus subtilisBiologyTransfer RNABiochemistryCysteineEnzymeBiosynthesisSulfurCofactorSulfur metabolismBacteriaChemistryGeneRNAGeneticsOrganic chemistryRNA modifications and cancerMetalloenzymes and iron-sulfur proteinsMetal-Organic Frameworks: Synthesis and Applications