Copper-catalyzed enantioselective fluoroalkenylation of cyclic imino esters
Zhiwei Chen, Xiang Huang, Jian Liao, Min Wang
Abstract
A copper-catalyzed enantioselective fluoroalkenylation of cyclic imino esters was developed. Using this protocol, tetrasubstituted monofluoroalkenes bearing a quaternary center were afforded in good yields with high E / Z -selectivities and excellent enantioselectivities.
Topics & Concepts
Enantioselective synthesisChemistryCopperCatalysisOrganic chemistryCombinatorial chemistryBearing (navigation)Medicinal chemistryCartographyGeographyFluorine in Organic ChemistryCatalytic C–H Functionalization MethodsCyclopropane Reaction Mechanisms