Alleviation effects of grape seed proanthocyanidin extract on inflammation and oxidative stress in a <scp>d</scp>-galactose-induced aging mouse model by modulating the gut microbiota
Kangliang Sheng, Jian Yang, Yifan Xu, Xiaowei Kong, Jingmin Wang, Yongzhong Wang
Abstract
Grape seed proanthocyanidin extract delayed the d -galactose-induced aging process in mice through the gut microbiota–liver axis and microbiota–brain axis.
Topics & Concepts
Oxidative stressAkkermansiaInflammationGut floraGlutathione peroxidaseGlutathionePharmacologyMalondialdehydeProanthocyanidinAntioxidantLachnospiraceaeChemistrySuperoxide dismutaseLactobacillusBiochemistryBiologyImmunologyPolyphenolFermentation16S ribosomal RNAFirmicutesGeneEnzymeAntioxidants, Aging, Portulaca oleraceaTryptophan and brain disordersGenomics, phytochemicals, and oxidative stress