Small Molecule Inhibitors of Lymphocyte Perforin as Focused Immunosuppressants for Infection and Autoimmunity
Julie A. Spicer, Kristiina M. Huttunen, Jiney Jose, Ivo Dimitrov, Hedieh Akhlaghi, Vivien R. Sutton, Ilia Voskoboinik, Joseph A. Trapani
Abstract
proof-of-concept experiments performed in mouse models of perforin-mediated immune pathologies that provide a potential pathway toward a clinically useful therapeutic agent.
Topics & Concepts
PerforinCTL*Immune systemImmunologyGranzymeAutoimmunityCytotoxic T cellBiologyCD8In vitroBiochemistryAutoimmune and Inflammatory Disorders ResearchAcute Lymphoblastic Leukemia researchChildhood Cancer Survivors' Quality of Life