Porous Titanium Dioxide Spheres for Drug Delivery and Sustained Release
Xingang Cui, Yi Chen, Qing-bang Ye, Xinyu Cui, Xiaojing Cui, Hongjing Cui, Guang-Zhi Shen, Miao-jing Li, Jiantao Lin, Yaxin Sun
Abstract
By hydrothermal method, porous TiO 2 spheres with pompon morphology are successfully synthesized in the tetrabutyl titanate (TBT)–acetic acid (HAc) system with no other additives. The morphological, structural and textural properties of the specimen are figured out by transmission electron microscopy (TEM), scanning electron microscopy (SEM), Fourier Transform Infrared Spectroscopy (FT-IR), X-ray powder diffraction (XRD), N 2 adsorption/desorption, and fluorescence microscope. The results show the pompon-like morphology of porous TiO 2 with high specific surface area and large pore volume, which can be used as a drug carrier. In this paper, doxorubicin hydrochloride (DOX) is chosen as drug model to understand the process of drug release. And results indicate that the porous TiO 2 is biocompatible and can be used for continuing drug-release, which shows lots of possibilities in medical fields.