Selonsertib Inhibits Liver Fibrosis via Downregulation of ASK1/ MAPK Pathway of Hepatic Stellate Cells
Young‐Chan Yoon, Zhenghuan Fang, Ji Eun Lee, Jung Hee Park, Ji‐Kan Ryu, Kyung Hee Jung, Soon‐Sun Hong
Abstract
. Taken together, selonsertib suppressed fibrotic response such as HSC proliferation and extracellular matrix components by blocking the ASK1/MAPK pathway. Therefore, we suggest that selonsertib may be an effective therapeutic drug for ameliorating liver fibrosis.
Topics & Concepts
Hepatic stellate cellASK1ApoptosisCell biologyFibrosisMAPK/ERK pathwayDownregulation and upregulationAnnexinCancer researchp38 mitogen-activated protein kinasesFibronectinKinaseIn vivoChemistryExtracellular matrixProtein kinase ABiologyMedicineMitogen-activated protein kinase kinaseInternal medicineEndocrinologyBiochemistryBiotechnologyGeneLiver physiology and pathologyLiver Disease Diagnosis and TreatmentHepatitis B Virus Studies