A diastereoselective synthesis of cyclopentanones<i>via</i>photocatalytic reductive alkyltrifluoromethylation of ynones
Jiayan Qiu, Siya Le, Jingwen Su, Yi Liu, Yulu Zhou, Hanliang Zheng, Yihui Bai, Gangguo Zhu
Abstract
A photocatalytic reductive alkyltrifluoromethylation of ynones with the Langlois reagent is developed, providing a regio- and diastereoselective access to trifluoromethylated cyclopentanones under mild conditions.
Topics & Concepts
ChemistryPhotocatalysisCombinatorial chemistryStereochemistryOrganic chemistryCatalysisFluorine in Organic ChemistryRadical Photochemical ReactionsSulfur-Based Synthesis Techniques