Accessing Chemo- and Regioselective Benzylic and Aromatic Oxidations by Protein Engineering of an Unspecific Peroxygenase
Anja Knorrscheidt, Jordi Soler Soler, Nicole Hünecke, Pascal Püllmann, Marc Garcia‐Borràs, Martin J. Weissenborn
Abstract
UPO variants represent a step forward toward the use and implementation of UPOs in biocatalytic synthetic pathways of industrial interest.
Topics & Concepts
RegioselectivityHydroxylationChemistryBiocatalysisProtein engineeringSubstrate (aquarium)Saccharomyces cerevisiaeEnzyme kineticsCombinatorial chemistryStereochemistryDirected evolutionEnzymeCatalysisActive siteComputational biologyYeastBiochemistryBiologyMutantGeneReaction mechanismEcologyEnzyme-mediated dye degradationMicrobial Natural Products and BiosynthesisEnzyme Catalysis and Immobilization