Isoorientin, a GSK-3β inhibitor, rescues synaptic dysfunction, spatial memory deficits and attenuates pathological progression in APP/PS1 model mice
Xiaoqin Tan, Zhibin Liang, Yingui Li, Yingkun Zhi, Lang Yi, Shasha Bai, Kelly H. Forest, Robert A. Nichols, Yan Dong, Qing X. Li
Topics & Concepts
NeuroinflammationNeuroscienceLong-term potentiationIsoorientinGSK-3NeuroprotectionHyperphosphorylationPsychologyMedicinePharmacologyBiologyKinaseInternal medicineInflammationCell biologyBiochemistryReceptorAntioxidantFlavonoidAlzheimer's disease research and treatmentsCholinesterase and Neurodegenerative DiseasesNicotinic Acetylcholine Receptors Study