The Combination of <i>Bacillus natto</i> JLCC513 and Ginseng Soluble Dietary Fiber Attenuates Ulcerative Colitis by Modulating the LPS/TLR4/NF-κB Pathway and Gut Microbiota
Mingyue Ma, Yueqiao Li, Yancheng He, Da Li, Honghong Niu, Mubai Sun, Xinyu Miao, Ying Su, Hua Zhang, Mei Hua, Jinghui Wang
Abstract
in the gut microbiota of UC mice. BG also significantly upregulated genes related to linoleic acid metabolism in the gut microbiota. These BG-induced changes in the gut microbiota of mice with UC were significantly correlated with changes in pathological indices. In conclusion, this study demonstrated that BG exerts protective effect against UC by regulating the LPS/TLR4/NF-κB pathway and the structure and metabolic function of gut microbiota. Thus, BG can be potentially used in intestinal health foods to treat UC.
Topics & Concepts
Ulcerative colitisGinsengMicrobiologyTLR4Gut floraColitisDietary fiberBiologyChemistryMedicineSignal transductionFood scienceBiochemistryImmunologyInternal medicineAlternative medicinePathologyDiseaseGut microbiota and healthProbiotics and Fermented FoodsPediatric health and respiratory diseases