SIRT1 attenuates neuroinflammation by deacetylating HSPA4 in a mouse model of Parkinson's disease

Yinuo Yang, Shouping Zhang, Jindong Guan, Yuhui Jiang, Jing Zhang, Lan Luo, Cheng Sun

2022Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease37 citationsDOI

Topics & Concepts

NeuroinflammationProinflammatory cytokinePars compactaNeurodegenerationSubstantia nigraMPTPNeuroprotectionMicrogliaSirtuin 1BiologyCell biologyGenetically modified mouseChemistryTransgeneNeuroscienceBiochemistryInflammationImmunologyMedicineDopamineInternal medicineDownregulation and upregulationDopaminergicDiseaseGeneSirtuins and Resveratrol in MedicineRNA regulation and diseaseEndoplasmic Reticulum Stress and Disease