Macrophage-derived hybrid exosome-mimic nanovesicles loaded with black phosphorus for multimodal rheumatoid arthritis therapy
Chengwu Zhao, Wen-Xia Song, Jie Ma, Nan Wang
Abstract
binding proinflammatory factors and releasing anti-inflammatory mediators. Furthermore, black phosphorus nanosheets (BP) were introduced into the HNV (HNV@BP) to eliminate inflammatory cells upon near-infrared (NIR) irradiation, which intrinsically decreases the inflammatory reaction. In a mouse model of collagen-induced arthritis, the HNV loaded with BP targeted and accumulated at the inflammed knee joints, exhibiting multimodal rheumatoid arthritis therapy combined with NIR irradiation through comprehensive inflammation suppression.
Topics & Concepts
Rheumatoid arthritisBlack phosphorusMacrophageExosomeMedicineChemistryImmunologyMicrovesiclesBiochemistrymicroRNAIn vitroGeneOptoelectronicsPhysicsExtracellular vesicles in diseaseSystemic Lupus Erythematosus ResearchAutoimmune and Inflammatory Disorders Research