Ox-LDL-induced CD80<sup>+</sup> macrophages expand pro-atherosclerotic NKT cells via CD1d in atherosclerotic mice and hyperlipidemic patients
Yin Wang, Yao Zou, Qingsong Jiang, Wenming Li, Xinyu Chai, Tingrui Zhao, Siyi Liu, Zhiyi Yuan, Chao Yu, Tingting Wang
Abstract
This work proposed the ox-LDL-CD80 + monocyte/macrophage-CD1d-NKT cell-IFN-γ axis in the progression of atherosclerosis. The proinflammatory IFN-γ + NKT cells are closely related to CD1d + CD80 + monocytes in hyperlipidemic patients. Inhibiting CD80 + macrophages to present lipid antigens to NKT cells through CD1d blocking may be a new therapeutic target for atherosclerosis.
Topics & Concepts
CD1DNatural killer T cellImmunologyImmune systemEx vivoCD1Innate immune systemBiologyT cellIn vivoBiotechnologyImmune Cell Function and InteractionImmune cells in cancerAtherosclerosis and Cardiovascular Diseases