Circulating resistin levels in relation with insulin resistance, inflammatory and endothelial dysfunction markers in patients with type 2 diabetes and impaired fasting glucose
Khalid Siddiqui, Salini Scaria Joy, Teena P. George
Abstract
Background Resistin is an adipose tissue secreted protein link with the mechanism involved in the pathophysiology of insulin resistance. Aim of the work This study aims to investigate the potential role of resistin in insulin resistance in relation with inflammatory markers and endothelial dysfunction markers in impaired fasting glucose (IFG) and type 2 diabetes (T2D). Patients and Methods This pilot study assess the relation of resistin with insulin resistance (HOMA-IR), adipokines (adiponectin, leptin), inflammatory markers [tumor necrosis factor-α (TNF-α), C-reactive protein (CRP), interleukin-6 (IL-6)] and endothelial dysfunction markers [vascular cell adhesion molecule-1 (VCAM-1), intercellular adhesion molecule-1 (ICAM-1)] cross-sectionally using serum samples obtained from 64 participants; controls (n=29), IFG (n=20) and T2D (n=15). The levels of biomarker were measured by using Randox Evidence biochip analyzer. Statistical analyses were performed by SPSS 21.0 software. Results Resistin levels in IFG and T2D groups were higher compared to control group. A positive correlation was detected between serum resistin levels with HOMA-IR (p= 0.02), inflammatory markers; TNF-α (p=<0.001), IL-6 (p=0.007) and endothelial dysfunction marker; VCAM-1 (p=0.02) in T2D group. In IFG group, resistin showed a significant positive correlation with IL-6 (p= 0.03). Conclusion The present study demonstrates the involvement of inflammation and endothelial dysfunction in relation with resistin linked insulin resistance in T2D. The promising insulin resistance biomarker-resistin- among people at high risk to develop type 2 diabetes mellitus and add significant contribution to this highly prevalent population .