Oxidative Sulfonylation of Hydrazones Enabled by Synergistic Copper/Silver Catalysis
Jun Xu, Chao Shen, Xian Qin, Jie Wu, Pengfei Zhang, Xiaogang Liu
Abstract
A copper/silver-cocatalyzed protocol for oxidative sulfonylation of hydrazones is demonstrated. A wide range of β-ketosulfones and N-acylsulfonamides are directly synthesized in moderate to good yields. Our work provides a viable method for scalable preparation of β-ketosulfone derivatives that have found wide applications in the pharmaceutical industry.
Topics & Concepts
ChemistryOxidative phosphorylationCopperHydrazoneCatalysisCombinatorial chemistryOrganic chemistryBiochemistrySulfur-Based Synthesis TechniquesChemical Synthesis and ReactionsCatalytic C–H Functionalization Methods