A snapshot love story: what serial crystallography has done and will do for us
Alessandra Henkel, Dominik Oberthür
Abstract
Serial crystallography, born from groundbreaking experiments at the Linac Coherent Light Source in 2009, has evolved into a pivotal technique in structural biology. Initially pioneered at X-ray free-electron laser facilities, it has now expanded to synchrotron-radiation facilities globally, with dedicated experimental stations enhancing its accessibility. This review gives an overview of current developments in serial crystallography, emphasizing recent results in time-resolved crystallography, and discussing challenges and shortcomings.
Topics & Concepts
Snapshot (computer storage)Synchrotron radiationLinear particle acceleratorSynchrotronComputer scienceLaserCrystallographyOpticsPhysicsChemistryDatabaseBeam (structure)Enzyme Structure and FunctionAdvanced X-ray Imaging TechniquesAdvanced Electron Microscopy Techniques and Applications