HDX-MS-optimized approach to characterize nanobodies as tools for biochemical and structural studies of class IB phosphoinositide 3-kinases
Manoj Kumar Rathinaswamy, Kaelin D. Fleming, Udit Dalwadi, Els Pardon, Noah J Harris, Calvin K. Yip, Jan Steyaert, John E. Burke
Topics & Concepts
Phosphoinositide 3-kinaseProtein subunitCell biologyPI3K/AKT/mTOR pathwaySignal transductionChemistryG protein-coupled receptorKinaseComputational biologyBiologyBiochemistryGeneMonoclonal and Polyclonal Antibodies ResearchReceptor Mechanisms and SignalingPI3K/AKT/mTOR signaling in cancer