Hemodiafiltration Is Associated With Reduced Inflammation and Increased Bone Formation Compared With Conventional Hemodialysis in Children: The HDF, Hearts and Heights (3H) Study
Dagmar-Christiane Fischer, Colette Smith, Francesca De Zan, Justine Bacchetta, Sevcan A. Bakkaloğlu, Ayşe Ağbaş, Ali Anarat, Bilal Aoun, Varvara Askiti, Karolis Ažukaitis, Aysun Karabay Bayazıt, İpek Kaplan Bulut, Nur Canpolat, Dagmara Borzych–Dużałka, Ali Düzova, Sandra Habbig, Saoussen Krid, Christoph Licht, Mieczysław Litwin, Łukasz Obrycki, Fabio Paglialonga, Anja Rahn, Bruno Ranchin, Charlotte Samaille, Mohan Shenoy, Manish D. Sinha, Brankica Spasojević, Constantinos J. Stefanidis, Enrico Vidal, Alev Yılmaz, Michel Fischbach, Franz Schaefer, Claus Peter Schmitt, Rukshana Shroff
Abstract
BACKGROUND: analysis of the prospective cohort study HDF, Hearts and Heights (3H) to determine the prevalence and risk factors for chronic kidney disease-related bone disease in children on hemodiafiltration (HDF) and conventional hemodialysis (HD). METHODS: The baseline cross-sectional analysis included 144 children, of which 103 (61 HD, 42 HDF) completed 12-month follow-up. Circulating biomarkers of bone formation and resorption, inflammatory markers, fibroblast growth factor-23, and klotho were measured. RESULTS: < .0001) after 12 months of HD compared with HDF. CONCLUSION: Children on HDF have an attenuated inflammatory profile, increased bone formation, and lower fibroblast growth factor-23/klotho ratios compared with those on HD. Long-term studies are required to determine the effects of an improved bone biomarker profile on fracture risk and cardiovascular health.