Nebulized Bacteriophage in a Patient With Refractory <i>Mycobacterium abscessus</i> Lung Disease
Rebekah M. Dedrick, Krista G. Freeman, Jan A. Nguyen, Asli Bahadirli-Talbott, Mitchell Cardin, Madison Cristinziano, Bailey E. Smith, Soowan Jeong, Elisa H. Ignatius, Cheng Ting Lin, Keira A. Cohen, Graham F. Hatfull
Abstract
Abstract An elderly man with refractory Mycobacterium abscessus lung disease previously developed anti-phage neutralizing antibodies while receiving intravenous phage therapy. Subsequent phage nebulization resulted in transient weight gain, decreased C-reactive protein, and reduced Mycobacterium burden. Weak sputum neutralization may have limited the outcomes, but phage resistance was not a contributing factor.
Topics & Concepts
MedicineMycobacterium abscessusBacteriophageRefractory (planetary science)SputumMicrobiologyVirologyMycobacteriumImmunologyTuberculosisPathologyBiologyEscherichia coliAstrobiologyBiochemistryGeneBacteriophages and microbial interactionsMycobacterium research and diagnosisPolyomavirus and related diseases