Trifluoromethylthiolation, Trifluoromethylation, and Arylation Reactions of Difluoro Enol Silyl Ethers
Xingguo Jiang, Denise N. Meyer, Dominik Baran, Miguel A. Cortés González, Kálmán J. Szabó
Abstract
group, which can be combined with the high electrophilicity of the difluoroketone motif. The methodology could also be extended to difluoro homologation of the trifluoromethyl ketones using the Togni reagent. In addition, we presented a method for transition-metal-free arylation of difluoro enol silyl ethers based on hypervalent iodines.
Topics & Concepts
Hypervalent moleculeSilylationEnolTrifluoromethylationElectrophileChemistryMoietyTrifluoromethylReagentElectrophilic fluorinationOrganic chemistryAlkylCatalysisFluorine in Organic ChemistryInorganic Fluorides and Related Compounds