TSC1 loss increases risk for tauopathy by inducing tau acetylation and preventing tau clearance via chaperone-mediated autophagy
Carolina Alquezar, Kathleen M. Schoch, Ethan G. Geier, Eliana Marisa Ramos, Aurora Scrivo, Kathy H. Li, Andrea R. Argouarch, Elisabeth E. Mlynarski, Beth A. Dombroski, Michael DeTure, Dennis W. Dickson, Jennifer S. Yokoyama, Ana María Cuervo, Alma L. Burlingame, Gerard D. Schellenberg, Timothy M. Miller, Bruce L. Miller, Aimee W. Kao
Abstract
haploinsufficiency as a genetic model for tauopathies. In addition, these findings promote tau acetylation as a rational target for tauopathy therapeutics and diagnostic.
Topics & Concepts
TauopathyAutophagyAcetylationTSC1Tau pathologyCell biologyNeuroscienceBiologyChemistryCancer researchMedicineInternal medicineNeurodegenerationBiochemistryAlzheimer's diseaseDiseaseSignal transductionApoptosisPI3K/AKT/mTOR pathwayGeneAlzheimer's disease research and treatmentsAutophagy in Disease and TherapyParkinson's Disease Mechanisms and Treatments