Effectiveness of omega-3 and prebiotics on adiponectin, leptin, liver enzymes lipid profile and anthropometric indices in patients with non-alcoholic fatty liver disease: A randomized controlled trial
Mahdieh Abbasalizad Farhangi, Parvin Dehghan, Vali Musazadeh, Maryam Kavyani, Parham Maleki
Abstract
This trial evaluated the combined effects of resistant dextrin and Camelina sativa oil (RDCSO) on anthropometric indices, lipid profile, atherogenic index (athero-index), liver enzymes, leptin, and adiponectin in 36 NAFLD patients receiving either intervention (RDCSO) or placebo (CSO + maltodextrin) for 12 weeks. Both groups were given a calorie-reduced diet. Anthropometric indices, aspartate aminotransferase (AST), alkaline phosphatase (ALP), triglycerides (TG), High-density lipoprotein cholesterol (HDL-c), high-sensitivity C- reactive protein (hs-CRP) and LPS improved significantly in both groups (p < 0.05). Body mass index (BMI), weight, waist circumference (WC), liver steatosis grade, ALT, ALP, AST/ALT ratio, TC, TG, LDL-c/HDL-c (Castelli II Index), Log TG/HDL-c (athero-index), hs-CRP, leptin, adiponectin and lipopolysaccharide (LPS) were different between the two groups at end of the intervention. Supplementation of RDCSO is more effective in improving lipid profile, athero-index, liver enzymes, adiponectin, metabolic endotoxemia and anthropometric indices in individuals with NAFLD than CSO supplementation alone. Trial registration number: This study was registered with the Iranian Registry of Clinical Trials website (www.irct.ir/, IRCT20150205020965N4 on 13-12-2019).