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From 18- to 20-electron ferrocene derivatives via ligand coordination

Satoshi Takebayashi, Jama Ariai, Sergey V. Kartashov, Robert R. Fayzullin, Tomoko Onoue, Ko Mibu, Hyung‐Been Kang, Noriko Ishizu

2025Nature Communications16 citationsDOIOpen Access PDF

Abstract

Abstract The 18-electron rule is a fundamental rule in coordination chemistry on which several revolutionary discoveries in catalysis and materials science are founded. This rule has classes of exceptions; however, it is widely taught and accepted that diamagnetic 18-electron complexes do not coordinate to a ligand to form a 20-electron complex even as a reaction intermediate. Here, based on tunable ligand design, we report the formation of 20-electron ferrocene derivatives through reversible nitrogen coordination to 18-electron analogs. Through theoretical studies, we have elucidated key features that enabled this coordination chemistry and how the nitrogen coordination shifts the metal−ligand bonding characters. These 20-electron ferrocene derivatives exhibit reversible Fe II /Fe III /Fe IV redox chemistry under previously unattainable, mild conditions. This work highlights the previously unknown coordination chemistry of diamagnetic 18-electron complexes, which underlies the foundation for future innovations in a range of synthetic chemistry.

Topics & Concepts

Coordination complexFerroceneLigand (biochemistry)ChemistryDiamagnetismReactivity (psychology)RedoxMetalComputational chemistryInorganic chemistryElectrochemistryPhysical chemistryOrganic chemistryPhysicsElectrodeMedicineMagnetic fieldPathologyAlternative medicineQuantum mechanicsReceptorBiochemistryFerrocene Chemistry and ApplicationsOrganometallic Complex Synthesis and CatalysisMetal-Organic Frameworks: Synthesis and Applications