Redox-dual-sensitive multiblock copolymer vesicles with disulfide-enabled sequential drug delivery
Cheng Cheng, Jiayun Ma, Jinling Zhao, Haiying Lu, Yang Liu, Chuanshi He, Man Lu, Xiaohong Yin, Jianshu Li, Mingming Ding
Abstract
Based on disulfide-enriched multiblock copolymer vesicles, we present a straightforward sequential drug delivery system with dual-redox response that releases hydrophilic doxorubicin hydrochloride (DOX·HCl) and hydrophobic paclitaxel (PTX) under oxidative and reductive conditions, respectively. When compared to concurrent therapeutic delivery, the spatiotemporal control of drug release allows for an improved combination antitumor effect. The simple and smart nanocarrier has promising applications in the field of cancer therapy.
Topics & Concepts
Doxorubicin HydrochlorideNanocarriersCopolymerDrug deliveryCombinatorial chemistryRedoxDisulfide bondPaclitaxelVesicleDrugMaterials scienceControlled releaseDoxorubicinAnticancer drugNanotechnologyReducing agentDrug carrierChemistryOrganic chemistryPharmacologyPolymerCancerChemotherapyBiochemistryMembraneMedicineInternal medicineSurgeryNanoparticle-Based Drug DeliveryNanoplatforms for cancer theranosticsDendrimers and Hyperbranched Polymers