ATP-competitive and allosteric inhibitors induce differential conformational changes at the autoinhibitory interface of Akt1
Alexandria L Shaw, Matthew AH Parson, Linda Truebestein, Meredith L. Jenkins, Thomas A. Leonard, John E. Burke
Topics & Concepts
Allosteric regulationProtein kinase BPleckstrin homology domainAKT1ChemistryPhosphorylationAKT2BiochemistryBiophysicsProto-Oncogene Proteins c-aktCell biologyEnzymeBiologyPI3K/AKT/mTOR signaling in cancerProtein Kinase Regulation and GTPase SignalingCancer-related gene regulation