Antiproliferative activity and toxicity evaluation of 1,2,3-triazole and 4-methyl coumarin hybrids in the MCF7 breast cancer cell line
Lucas Volnei Augsten, Gabriela Göethel, Bruna Gauer, Mariele Feiffer Charão, Gilsane Lino von Poser, Rômulo Faria Santos Canto, Marcelo Dutra Arbo, Vera Lúcia Eifler-Lima, Solange Cristina García
Abstract
Coumarin–triazole hybrids went through antitumor activity screening, finding anti-breast cancer cell line MCF7 activity, besides antioxidant activity, mitochondrial membrane disruption and no DNA damage.
Topics & Concepts
CisplatinApoptosisCancerPharmacologyToxicityCancer researchCancer cellChemistryBiologyBiochemistryChemotherapyGeneticsOrganic chemistrySynthesis and biological activityClick Chemistry and ApplicationsCancer therapeutics and mechanisms