A validated LC-MS/MS analytical method for the quantification of pemigatinib: metabolic stability evaluation in human liver microsomes
Mohamed W. Attwa, Ali S. Abdelhameed, Nawaf A. Alsaif, Adnan A. Kadi, Haitham AlRabiah
Abstract
, respectively. PMB showed a moderate extraction ratio suggesting good bioavailability. The developed analytical method is the first LC-MS/MS method specific for PMB quantification with application to metabolic stability assessment.
Topics & Concepts
ChromatographyHuman liverMicrosomeChemistryBiochemistryEnzymeFibroblast Growth Factor ResearchNeuroendocrine Tumor Research AdvancesMetabolism, Diabetes, and Cancer