Metal–organic framework combined with CaO<sub>2</sub> nanoparticles for enhanced and targeted photodynamic therapy
Xinran Sun, Kaixiu Chen, Yingyan Liu, Guoda Zhang, Min Shi, Pengfei Shi, Shusheng Zhang
Abstract
A self-supplying O 2 nanosystem based on MOF combined with hyaluronate-modified CaO 2 (PCN-224-CaO 2 -HA) was constructed. This nanosystem can be used for targeted and enhanced photodynamic therapy in vitro and in vivo .
Topics & Concepts
Photodynamic therapyIn vivoCancer researchIn vitroCD44Tumor hypoxiaPorphyrinChemistryPharmacologyMedicineRadiation therapyBiologyInternal medicineBiochemistryBiotechnologyOrganic chemistryNanoplatforms for cancer theranosticsPhotodynamic Therapy Research StudiesCancer, Hypoxia, and Metabolism