Calcium-dependent ESCRT recruitment and lysosome exocytosis maintain epithelial integrity during Candida albicans invasion
Johannes Westman, Jonathan Plumb, Anna F. Licht, Mabel Yang, Stefanie Allert, Julian R. Naglik, Bernhard Hube, Sergio Grinstein, Michelle E. Maxson
Abstract
and loss of cortical actin. Epithelial cells dispose of damaged membrane regions containing candidalysin by an Alg-2/Alix/ESCRT-III-dependent blebbing process. At later stages, plasmalemmal tears induced mechanically by invading hyphae are repaired by exocytic insertion of lysosomal membranes. These two repair mechanisms maintain epithelial integrity and prevent mucosal damage during both commensal growth and infection by C. albicans.
Topics & Concepts
Candida albicansESCRTHyphaCell biologySecretionBiologyExocytosisMicrobiologyIntracellularBiochemistryEndosomeAntifungal resistance and susceptibilityFungal Infections and StudiesAntimicrobial Peptides and Activities