The relationship between elastin cross linking and alveolar wall rupture in human pulmonary emphysema
Michael Fagiola, Sandra E. Reznik, Muhammad Riaz, Yibing Qyang, Seo Yeon Lee, Joseph Avella, Gerard Turino, Jerome Cantor
Abstract
The current findings support the hypothesis that airspace enlargement is an emergent phenomenon in which initial proliferation of DID cross links to counteract alveolar wall distention is followed by a phase transition involving rapid acceleration of elastin breakdown, alveolar wall rupture, and progression to an active disease state that is less amenable to therapeutic intervention.
Topics & Concepts
ElastinMedicineLungCardiologyInternal medicinePathologyConnective tissue disorders researchNeonatal Respiratory Health ResearchFibroblast Growth Factor Research