Immunotherapy approaches for hematological cancers
Olivia L. Lanier, Edgar Pérez‐Herrero, Abielle P. D.’ Andrea, Kiana Bahrami, Elaine Lee, Deidra M. Ward, Nilaya Ayala-Suárez, Sheyla M. Rodríguez-Méndez, Nicholas A. Peppas
Abstract
Hematological cancers such as leukemia, lymphoma, and multiple myeloma have traditionally been treated with chemo and radiotherapy approaches. Introduction of immunotherapies for treatment of these diseases has led to patient remissions that would not have been possible with traditional approaches. In this critical review we identify main disease characteristics, symptoms, and current treatment options. Five common immunotherapies, namely checkpoint inhibitors, vaccines, cell-based therapies, antibodies, and oncolytic viruses, are described, and their applications in hematological cancers are critically discussed.