On the application of 3d metals for C–H activation toward bioactive compounds: The key step for the synthesis of silver bullets
Renato L. Carvalho, Amanda Silva de Miranda, Mateus P. Nunes, Roberto da Silva Gomes, Guilherme A. M. Jardim, Eufrânio N. da Silva Júnior
Abstract
Several valuable biologically active molecules can be obtained through C-H activation processes. However, the use of expensive and not readily accessible catalysts complicates the process of pharmacological application of these compounds. A plausible way to overcome this issue is developing and using cheaper, more accessible, and equally effective catalysts. First-row transition (3d) metals have shown to be important catalysts in this matter. This review summarizes the use of 3d metal catalysts in C-H activation processes to obtain potentially (or proved) biologically active compounds.
Topics & Concepts
ChemistryCatalysisCombinatorial chemistryNanotechnologyTransition metalMoleculeMetalOrganic chemistryMaterials scienceCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsAsymmetric Hydrogenation and Catalysis