The murburn precepts for cellular ionic homeostasis and electrophysiology
Kelath Murali Manoj, N. M. Bazhin, Hirohisa Tamagawa
Abstract
Abstract Starting from the basic molecular structure and redox properties of its components, we build a macroscopic cellular electrophysiological model. We first present a murburn purview that could explain ion distribution in bulk‐milieu/membrane‐interface and support the origin of trans‐membrane potential (TMP) in cells. In particular, the discussion focuses on how cells achieve disparity in the distribution of monovalent and divalent cations within (K + > Na + > Mg 2+ > Ca 2+ ) and outside (Na + > K + > Ca 2+ > Mg 2+ ). We explore how TMP could vary for resting/graded/action potentials generation and project a model for impulse conduction in neurons. Outcomes based on murburn bioenergetic equilibriums leading to solubilization of ion‐pairs, membrane's permittivity, protein channels' fluxes, and proteins’ innate ability to bind/adsorb ions selectively are projected as the integral rationale. We also provide experimental modalities to ratify the projections.