Distribution of Gadolinium-based Contrast Agent after Leaking into the Cerebrospinal Fluid: Comparison between the Cerebral Cisterns and the Lateral Ventricles
Toshio Ohashi, Shinji Naganawa, Saeko Iwata, Kayao Kuno
Abstract
PURPOSE: Leakage of a small amount of intravenously administered gadolinium-based contrast agents (GBCAs) into the cerebrospinal fluid (CSF) space has been reported, even in healthy subjects without blood-brain barrier disruption. Several candidates including the choroid plexus and cortical veins have been proposed as the source of the leakage. The purpose of this study was to evaluate the distribution of intravenously administered GBCA leakage into the CSF by comparing the contrast enhancement of the cerebral cisterns to the lateral ventricles (LVs). METHODS: in each region were evaluated at 5 min and 4 h post-IV-SD-GBCA. A Steel-Dwass's test was applied to correct for multiple comparisons. RESULTS: , and the Vit at 4 h post-IV-SD-GBCA (P < 0.05). CONCLUSION: The contrast enhancement in the cerebral cisterns was greater than that in the LVs.