Hyaluronic acid–green tea catechin conjugates as a potential therapeutic agent for rheumatoid arthritis
Fan Lee, Ki Hyun Bae, Shengyong Ng, Atsushi Yamashita, Motoichi Kurisawa
Abstract
HA-CD44 interactions. These conjugates exhibited superior anti-proliferative and anti-inflammatory activities compared with EGCG under simulated physiological conditions. Near-infrared fluorescence imaging revealed preferential accumulation of the conjugates at inflamed joints in a collagen-induced arthritis rat model, and their anti-arthritic efficacy was investigated by measuring a change in the edema and histopathological scores. Our findings suggest the potential of HA-EGCG conjugates as an anti-arthritic agent for the treatment of rheumatoid arthritis.
Topics & Concepts
Hyaluronic acidInternalizationRheumatoid arthritisConjugateCD44ChemistryCatechinSecretionFibroblastPharmacologyPapainArthritisCancer researchBiochemistryCellMedicineImmunologyPolyphenolAntioxidantIn vitroEnzymeMathematical analysisAnatomyMathematicsTea Polyphenols and EffectsChemokine receptors and signalingImmunotherapy and Immune Responses