Preparation of Oxindoles via Visible‐Light‐Induced Amination/Cyclization of Arylacrylamides with Alkyl Amines
Yu‐Zhao Wang, Wu‐Jie Lin, Jian‐Yu Zou, Wei Yu, Xue‐Yuan Liu
Abstract
Abstract The cascade amination/cyclization of N ‐arylacrylamides with alkyl amines under visible‐light photoredox catalysis is realized via intermediacy of aminium radicals. The aminium radicals are generated by a two‐step sequence which involves N‐chlorination of alkyl amines and subsequent reductive N−Cl cleavage. This method provides a convenient access to aminated oxindoles. magnified image
Topics & Concepts
ChemistryAminationAlkylRadicalReductive aminationPhotoredox catalysisCleavage (geology)Visible spectrumCatalysisCascadePhotochemistryCombinatorial chemistryOrganic chemistryPhotocatalysisGeotechnical engineeringOptoelectronicsEngineeringPhysicsFracture (geology)ChromatographyRadical Photochemical ReactionsCatalytic C–H Functionalization MethodsSulfur-Based Synthesis Techniques