The E3 ubiquitin ligase CHIP protects against sepsis-induced myocardial dysfunction by inhibiting NF-κB-mediated inflammation via promoting ubiquitination and degradation of karyopherin-α 2
Jia Liao, Xingyu Su, Miao Wang, Lucen Jiang, Xi Chen, Zixi Liu, Guoqing Tang, Li Zhou, Hongmei Li, Xiuxiu Lv, Jun Yin, Huadong Wang, Yiyang Wang
Topics & Concepts
UbiquitinUbiquitin ligaseKaryopherinInflammationNF-κBNFKB1Cell biologyDNA ligaseUbiquitin-Protein LigasesChemistryCancer researchMedicineBiologyImmunologyBiochemistryTranscription factorEnzymeNuclear transportNucleusGeneCell nucleusMitochondrial Function and PathologyAdipose Tissue and MetabolismInflammasome and immune disorders