Distinct time courses and mechanics of right ventricular hypertrophy and diastolic stiffening in a male rat model of pulmonary arterial hypertension
Ethan D. Kwan, Daniela Vélez‐Rendón, Xiaoyan Zhang, Hao Mu, Megh Patel, Erica Pursell, Jennifer Stowe, Daniela Valdez‐Jasso
Abstract
Using a novel combination of hemodynamic and morphological measurements over 10 wk in a male rat model of PAH and a mathematical model of RV mechanics, we found that compensated systolic function was almost entirely explained by RV hypertrophy, but subsequently altered RV end-diastolic mechanics were primarily explained by passive myocardial stiffening that was not associated with significant collagen extracellular matrix accumulation.
Topics & Concepts
CardiologyStiffeningInternal medicineDiastolic functionDiastoleMuscle hypertrophyExtracellular matrixHemodynamicsMyocardial hypertrophyMedicineBlood pressureChemistryStructural engineeringEngineeringBiochemistryPulmonary Hypertension Research and TreatmentsCardiovascular Function and Risk FactorsCardiomyopathy and Myosin Studies