Solid-state aromatic nucleophilic fluorination: a rapid, practical, and environmentally friendly route to N-heteroaryl fluorides
Koji Kubota, Tetsu Makino, Keisuke Kondo, Tamae Seo, Mingoo Jin, Hajime Ito
Abstract
A simple mechanochemical protocol for solid-state aromatic nucleophilic fluorination using potassium fluoride (KF) and quaternary ammonium salts was developed.
Topics & Concepts
Environmentally friendlyNucleophileChemistrySolid-stateOrganic chemistryHalogenationNucleophilic aromatic substitutionCombinatorial chemistryNucleophilic substitutionCatalysisBiologyPhysical chemistryEcologyFluorine in Organic Chemistry