Projection of Gut Microbiome Pre- and Post-Bariatric Surgery To Predict Surgery Outcome
Meirav Ben Izhak, Adi Eshel, Ruti Cohen, Liora Madar-Shapiro, Hamutal Meiri, Chaim Wachtel, Conrad L. Leung, Edward Messick, Narisra Jongkam, Eli Mavor, Shimon Sapozhnikov, Nitsan Maharshak, Subhi Abu‐Abeid, Avishai Alis, Ilanit Mahler, Aviel Meoded, Shai Meron Eldar, Omry Koren, Yoram Louzoun
Abstract
BMI and diabetes can affect the gut microbiome composition. Bariatric surgery has large variabilities in the outcome. The microbiome was previously shown to be a good predictor for multiple diseases. We analyzed here the gut microbiome before and after bariatric surgery and showed the following. (i) The microbiome before surgery can be used to predict surgery outcomes. (ii) The postsurgery microbiome drifts further away from the lean microbiome than the microbiome of the presurgery obese patients. These results can lead to a microbiome-based presurgery decision whether to perform surgery.