Photoinduced Three-Component 1,2-Dicarbofunctionalization of Unactivated Alkenes via Polarity-Matched Control
Panyi Huang, Ting He, Xinyu Li, Bin Sun, Yongmin Ma
Abstract
We herein present a polarity-matched, light-induced radical strategy that enables the direct 1,2-heteroarylalkylation of alkenes using a range of commercially available alkyl bromides and heteroarenes under catalyst- and additive-free conditions. This transformation proceeds under mild reaction conditions, exhibits excellent chemoselectivity, and demonstrates a broad substrate scope (42 examples), including derivatives of pharmaceuticals and natural products.
Topics & Concepts
ChemistryComponent (thermodynamics)Polarity (international relations)Control (management)AlkeneCombinatorial chemistryPhotochemistryOrganic chemistryCatalysisComputer scienceArtificial intelligenceBiochemistryCellPhysicsThermodynamicsRadical Photochemical ReactionsSulfur-Based Synthesis TechniquesCatalytic C–H Functionalization Methods