Substrate-dependent oxidative inactivation of a W-dependent formate dehydrogenase involving selenocysteine displacement
Guilherme Vilela‐Alves, Rita R. Manuel, Aldino Viegas, Philippe Carpentier, Frédéric Biaso, Bruno Guigliarelli, Inês A. C. Pereira, Maria João Romão, Cristiano Mota
Abstract
Our study shows, at near-atomic resolution, how W- Dv FdhAB inactivates over time when exposed to either of its substrates and O 2 .
Topics & Concepts
SelenocysteineFormate dehydrogenaseSubstrate (aquarium)FormateChemistryDehydrogenaseBiochemistryEnzymeBiologyCysteineCatalysisEcologyMetalloenzymes and iron-sulfur proteinsMass Spectrometry Techniques and ApplicationsPhotosynthetic Processes and Mechanisms