Trans-omic analysis reveals obesity-associated dysregulation of inter-organ metabolic cycles between the liver and skeletal muscle
Riku Egami, Toshiya Kokaji, Atsushi Hatano, Katsuyuki Yugi, Miki Eto, Keigo Morita, Satoshi Ohno, Masashi Fujii, Ken‐ichi Hironaka, Saori Uematsu, Akira Terakawa, Yunfan Bai, Yifei Pan, Takaho Tsuchiya, Haruka Ozaki, Hiroshi Inoue, Shinsuke Uda, Hiroyuki Kubota, Yutaka Suzuki, Masaki Matsumoto, Keiichi I. Nakayama, Akiyoshi Hirayama, Tomoyoshi Soga, Shinya Kuroda
Abstract
mice, we provided potential mechanisms of the obesity-associated dysfunctions of metabolic cycles between liver and skeletal muscle involving glucose-alanine, glucose-lactate, and ketone bodies. Our study revealed obesity-associated systemic pathological mechanisms of dysfunction of inter-organ metabolic cycles.
Topics & Concepts
MetabolomeSkeletal muscleBiologyInternal medicineEndocrinologyMetabolomicsLeptinTranscriptomeGlucose homeostasisHomeostasisObesityKetone bodiesMetabolic syndromeMetabolismBioinformaticsInsulin resistanceMedicineBiochemistryGene expressionGeneDiet and metabolism studiesAdipose Tissue and MetabolismMetabolism, Diabetes, and Cancer