Regulation of fatty acid synthase on tumor and progress in the development of related therapies
Rilan Bai, Jiuwei Cui
Abstract
ABSTRACT: Fatty acid synthase (FASN) is an essential molecule in lipid metabolic pathways, which are crucial for cancer-related studies. Recent studies have focused on a comprehensive understanding of the novel and important regulatory effects of FASN on malignant biological behavior and immune-cell infiltration, which are closely related to tumor occurrence and development, immune escape, and immune response. FASN-targeting antitumor treatment strategies are being developed. Therefore, in this review, we focused on the effects of FASN on tumor and immune-cell infiltration and reviewed the progress of related anti-tumor therapy development.
Topics & Concepts
Fatty acid synthaseImmune systemCancer researchBiologyLipid metabolismImmunologyBiochemistryCancer, Lipids, and MetabolismPeroxisome Proliferator-Activated ReceptorsCancer, Hypoxia, and Metabolism